THE EFFECT OF LEAVAMINOLE ON GLUCOSE OXIDATION IN CACCHAROMYCES CERVISEAE. Nika Hastey; and mentor, Dr. Richard Pointer, Department of Biochemistry, Howard University, Washington, DC. The oxidation of glucose invloves combining oxidation with glucose and breaking it down to produce carbon dioxide, water and energy. This breakdown of glucose invloves two biological processes: glycolysis and cellular respiration. During glycolysis, glucose, a six-carbon sugar, is catabolized to produce two molecules of pyruvate, a three-carbon sugar. These two molecules of pyruvate then participate in cellular respiration, during which carbon dioxide, water, and energy are produced. The following chemical equation summarizes the reaction: The purpose of this experiment was to determine the effect of levamisole on glucose oxidation in Saccharomyces cerviseae, a species of yeast. Levamisole is the sulfur-containing L-isomer of tetramisole and a drug that has been used in clinical trails as a treatment for certatin types of skin and colon cancers. Although it exhibits varied actions on different metabolic enzymes, levamisole is generally known as a drug that inhibits glucose oxidation. For example, in Ascaris suum it inhibits the activity of glycogen phosphorylase. Overall, levamisole interferes with the completion of glucose oxidation, but it does this via varied mechanisms, depending on the orgarism. Essentially, this experiment invloved combining yeast, radioactive glucose, and levamisole in a test tube and witnessing the activity of the biological system by using a radiocative scintillator. Through my studies, I was able to observe and confirm the inhibitory effects of levamisole on glucose oxidation. Tracing the exact directly is a potential next step in the futher development of this study.			Nika Nakia Hastey, a senoir whose major is biology and minor mathematics/chemistry, is eagerly anticipation graduate school where she will major in biology and/or mathematics. Hastey describes her intrest in pursuing a Ph.D. degree as stemming from her long-held intrest in biology and mathematics. In recommending Hastey for the McNair Program, her professor in plant physiology described her as a diligent student with "exellent analytical reasoning skills." Another professor commented on her outstanding job as a faclitator in the Howard University Young Scholar Program, a program that prepares and motivates students towards science and a college education. Hastey is originally from Annapolis, Maryladnd. McNair Alumni